Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)
As such, youre prone to dehydration and the loss of critical nutrients and minerals
If it looks cloudy, has particles, or has changed color, don't use it
Such deviations could increase the risk of adverse effects, particularly gastrointestinal symptoms, and may affect glycemic control or weight management outcomes
However, the comparison among GLP-1 RAs on cardiovascular outcomes is limited
Troubleshooting Having issues with injecting your semaglutide medication